Log-normal based mutation evolutionary programming technique for solving economic dispatch problem considering loss minimization

Electricity delivery to the consumer should be implemented in such a way that, cost is minimal, loss is minimal and voltage is within the acceptable limit. In general, the voltage level should be within 95% to 105% of the nominal limit in accordance to most international standard within the power engineering community. This phenomenon is addressed as secure voltage level. The dispatch of electricity is controlled by a dispatch body of the utility in a country. Economic dispatch requires a reliable optimization technique so loss is minimal. This paper presents Log-Normal Evolutionary Programming (LNEP) technique for solving Economic Dispatch (ED) problem considering loss minimization. Validations on the IEEE 6-bus and IEEE 26-bus test systems demonstrated that LNEP is feasible and convincing is addressing the issues. It was revealed that the proposed LNEP gives better solution to solve ED problem than the Classical EP and traditional load flow.Keywords: economic dispatch; evolutionary programming, optimizatio

Critical Success Factors in Sustainable Credit Risk Model Among Manufacturing Companies in Malaysia

Credit risk is always foreseen as an analytical measurement adopted and employed by banking industry in Malaysia. It becomes critical in measuring the borrowers’ financial strength before the loan can be granted. In order to get a deep analysis, overview from different aspect is recommended. Financial and non-financial factor including the sustainable criteria are adopted in credit risk model. This pilot study was conducted to investigate critical success factor towards successful sustainable credit risk model among manufacturing companies in Malaysia. The questionnaires were design and distributed to the respondents. The result of reliability test shows that profitability is a critical factor influencing the successful of measurement of credit risk analysis compare to others factor. This study recommend that the future research explore the influence of sustainable credit risk model to different industry by consider more variables

Polymer-based protein delivery systems for loco-regional administration

With the advent of recombinant technology, a wide variety of biocompatible therapeutic proteins can be produced with relative ease. These proteins are formulated and subsequently administered in patients to treat various of diseases in a more effective and targeted manner. At the level of formulation development, protein molecules can be physically and/or chemically-conjugated to a wide array of naturally-occurring, semi-synthetic and synthetic biomaterials to form different types of protein delivery systems. Depending on their architecture and the extent of protein-scaffold interactions, these delivery systems can modify the pharmacokinetic and pharmacodynamic properties of the proteins. The versatility of polymer-based protein delivery systems such as micro/nanoparticles, hydrogels, porous scaffolds and fibrous scaffolds means it is possible to alter the spatial distribution of the protein load within the system as well as the protein release kinetics. These can then influence the ability of the protein molecules to exert their effects in their immediate microenvironments, be it to kill cancer cells or to recruit stem/progenitor cells. In this Chapter we discuss the production of protein therapeutics and the application of polymer-based biodegradable delivery systems for these proteins which include nanoparticles and scaffolds. We also include discussion of ‘green synthesis’ methods for production of these delivery systems

Microfluidic-assisted ZIF-silk-polydopamine nanoparticles as promising drug carriers for breast cancer therapy

Metal–organic frameworks (MOFs) are heralded as potential nanoplatforms for biomedical applications. Zeolitic imidazolate framework-8 (ZIF-8), as one of the most well known MOFs, has been widely applied as a drug delivery carrier for cancer therapy. However, the application of ZIF-8 nanoparticles as a therapeutic agent has been hindered by the challenge of how to control the release behaviour of anti-cancer zinc ions to cancer cells. In this paper, we designed microfluidic-assisted core-shell ZIF-8 nanoparticles modified with silk fibroin (SF) and polydopamine (PDA) for sustained release of zinc ions and curcumin (CUR) and tested these in vitro in various human breast cancer cells. We report that microfluidic rapid mixing is an efficient method to precisely control the proportion of ZIF-8, SF, PDA, and CUR in the nanoparticles by simply adjusting total flow rates (from 1 to 50 mL/min) and flow rate ratios. Owing to sufficient and rapid mixing during microfluidic-assisted nanoprecipitation, our designer CUR@ZIF-SF-PDA nanoparticles had a desired particle size of 170 nm with a narrow size distribution (PDI: 0.08), which is much smaller than nanoparticles produced using traditional magnetic stirrer mixing method (over 1000 nm). Moreover, a properly coated SF layer successfully enhanced the capability of ZIF-8 as a reservoir of zinc ions. Meanwhile, the self-etching reaction between ZIF-8 and PDA naturally induced a pH-responsive release of zinc ions and CUR to a therapeutic level in the MDA-MB-231, SK-BR-3, and MCF-7 breast cancer cell lines, resulting in a high cellular uptake efficiency, cytotoxicity, and cell cycle arrest. More importantly, the high biocompatibility of designed CUR@ZIF-SF-PDA nanoparticles remained low in cytotoxicity on AD-293 non-cancer cells. We demonstrate the potential of prepared CUR@ZIF-SF-PDA nanoparticles as promising carriers for the controlled release of CUR and zinc ions in breast cancer therapy

Performance and emission characteristics of a spark ignition engine fuelled with butanol isomer-gasoline blends

The heavy reliance on petroleum-derived fuels such as gasoline in the transportation sector is one of the major causes of environmental pollution. For this reason, there is a critical need to develop cleaner alternative fuels. Butanol is an alcohol with four different isomers that can be blended with gasoline to produce cleaner alternative fuels because of their favourable physicochemical properties compared to ethanol. This study examined the effect of butanol isomer-gasoline blends on the performance and emission characteristics of a spark ignition engine. The butanol isomers; n-butanol, sec-butanol, tert-butanol and isobutanol are mixed with pure gasoline at a volume fraction of 20 vol%, and the physicochemical properties of these blends are measured. Tests are conducted on a SI engine at full throttle condition within an engine speed range of 1000–5000 rpm. The results show that there is a significant increase in the engine torque, brake power, brake specific fuel consumption and CO2 emissions with respect to those for pure gasoline. The butanol isomers-gasoline blends give slightly higher brake thermal efficiency and exhaust gas temperature than pure gasoline at higher engine speeds. The iBu20 blend (20 vol% of isobutanol in gasoline) gives the highest engine torque, brake power and brake thermal efficiency among all of the blends tested in this study. The isobutanol and n-butanol blend results in the lowest CO and HC emissions, respectively. In addition, all of the butanol isomer-gasoline blends yield lower NO emissions except for the isobutanol-gasoline blend

Humane Orientation as a New Cultural Dimension of the GLOBE Project: A Validation Study of the GLOBE Scale and Out-Group Humane Orientation in 25 Countries

We validate, extend, and empirically and theoretically criticize the cultural dimension of humane orientation of the project GLOBE (Global Leadership and Organizational Behavior Effectiveness Research Program). Theoretically, humane orientation is not just a one-dimensionally positive concept about being caring, altruistic, and kind to others as discussed by Kabasakal and Bodur (2004), but there is also a certain ambivalence to this concept. We suggest differentiating humane orientation toward in-group members from humane orientation toward out-group members. A multicountry construct validation study used student samples from 25 countries that were either high or low in humane orientation (N = 876) and studied their relation to the traditional GLOBE scale and other cultural-level measures (agreeableness, religiosity, authoritarianism, and welfare state score). Findings revealed a strong correlation between humane orientation and agreeableness, welfare state score, and religiosity. Out-group humane orientation proved to be the more relevant subfacet of the original humane orientation construct, suggesting that future research on humane orientation should make use of this measure instead of the vague original scale. The ambivalent character of out-group humane orientation is displayed in its positive correlation to high authoritarianism. Patriotism was used as a control variable for noncritical acceptance of one's society but did not change the correlations. Our findings are discussed as an example of how rigid expectations and a lack of tolerance for diversity may help explain the ambivalent nature of humane orientation. © The Author(s) 2012

Exploring the cost-effectiveness of high versus low perioperative fraction of inspired oxygen in the prevention of surgical site infections among abdominal surgery patients in three low- and middle-income countries

Background: This study assessed the potential cost-effectiveness of high (80–100%) vs low (21–35%) fraction of inspired oxygen (FiO2) at preventing surgical site infections (SSIs) after abdominal surgery in Nigeria, India, and South Africa. Methods: Decision-analytic models were constructed using best available evidence sourced from unbundled data of an ongoing pilot trial assessing the effectiveness of high FiO2, published literature, and a cost survey in Nigeria, India, and South Africa. Effectiveness was measured as percentage of SSIs at 30 days after surgery, a healthcare perspective was adopted, and costs were reported in US dollars ($). Results: High FiO2 may be cost-effective (cheaper and effective). In Nigeria, the average cost for high FiO2 was$216 compared with $222 for low FiO2 leading to a −$6 (95% confidence interval [CI]: −$13 to −$1) difference in costs. In India, the average cost for high FiO2 was $184 compared with$195 for low FiO2 leading to a −$11 (95$15 to −$6) difference in costs. In South Africa, the average cost for high FiO2 was$1164 compared with $1257 for low FiO2 leading to a −$93 (95% CI: −$132 to −$65) difference in costs. The high FiO2 arm had few SSIs, 7.33% compared with 8.38% for low FiO2, leading to a −1.05 (95% CI: −1.14 to −0.90) percentage point reduction in SSIs. Conclusion: High FiO2 could be cost-effective at preventing SSIs in the three countries but further data from large clinical trials are required to confirm this